Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
نویسندگان
چکیده
Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co-workers demonstrate that coating mitochondria with a dextran-triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria.
منابع مشابه
Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration
Aberrant mitochondrial energy transfer underlies prevalent chronic health conditions, including cancer, cardiovascular, and neurodegenerative diseases. Mitochondrial transplantation represents an innovative strategy aimed at restoring favorable metabolic phenotypes in cells with dysfunctional energy metabolism. While promising, significant barriers to in vivo translation of this approach abound...
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